DANA IORDĂCHESCU*, MIHAELA ENACHE*, VALERIA TICA*, MIHAELA STĂNESCU*, D. CHETA**, T. NICOLAE***, GABRIELA ORĂȘANU**

*Research Center for Biochemistry and Molecular Biology, University of Bucharest, Romania
**”Prof. N. Paulescu” Nutrition and Metabolic Disease Institute, Bucharest, Romania
***Central Military Hospital, Bucharest, Romania

Abstract. Diabetes-prone BioBreeding (DP-BB) rat develops a spontaneous disorder that closely resembles human insulin-dependent (type I) diabetes mellitus, but the initial events that cause the diabetes onset remain largely unknown. Administration of metavanadate, an insulin mimetic agent. has been shown to normalize the glucose-6-phosphate level in the liver and to decrease hyperglycemia in DP-BB rat. The purpose of this study was to investigate the effects of vanadium administered in the drinking water to BB rat on the hydrolytic and phosphotransferasic activities of hepatic microsomal G6Pase. This treatment decreased the both activities, proportionally to the dose applied, the phosphotranslerase activity to a greater extent. Elevated level of carbamyl phosphate: glucose phosphotraisferase activity at 83 days from the treatment ceasing may explain the success obtained in postponing diabetes onset.

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