G. DAMIAN*, V. MICLĂUŞ**

*Dept. of Biomedical Physics, Physics Faculty, “Babeş-Bolyai” University, 1A, Kogălniceanu st, 400084 Cluj-Napoca, Romania
**Chemistry and Chemical Engineering Faculty, “Babeş-Bolyai” University, 11, Arany János st, 400028 Cluj-Napoca, Romania

Abstract. Spin trapping Electron Spin Resonance (ESR) spectroscopy was used to investigate the free radicals in γ-irradiated microcristalline powder form of 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy benzamide monohydrochloride monohydrate (metoclopramide). ESR measurements proved that contained various stable paramagnetic species after irradiation and relative yielding of the free radicals depends on the adsorbed dose. Specific radicals derived from purely chemical structures of metroclopramide, were detected using N-t-Butyl- α-phenylnitrone (PBN) as spin trap. Some spectroscopic properties and suggestions concerning possible structure of the radicals are discussed in this paper.

Author’s e-mail: dgrig@phys.ubbcluj.ro

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