ALINA VASILICA MANOLE*, V. MELNIG*, R. ZONDA**, CLAUDIA VĂCĂREANU*, SILVIA ALINA CHIPER*

* Faculty of Physics, “Al.I. Cuza” University, 11A, Carol I Blvd, 700506, Iaşi
** Faculty of Chemistry, “Gh. Asachi” University, 71A, D. Mangeron Blvd, 700050, Iaşi

The in vitro response of human platelets was studied upon adherence to films/membranes of polyurethanes with different soft segments: polyurethane with segment lactate comparatively with poly(esterurethane) precursor, in order to promote poly(lactateurethane) as candidate for limit blood-contacting materials. For optimizing the material, the surface energy was increased by dielectric barrier discharge in He and the results were compared with those of pristine films/membranes. In vitro platelet adhesion and the degree of hemolysis were determined by preliminary blood compatibility assessment, using the direct contact method, and the morphology of adhering platelets was studied by scanning electron microscopy. The most hydrophilic surfaces appear to cause least activation and aggregation of platelets

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