V.R. MURTHY, D.V. RAGHURAM, P.N. MURTHY

Department of Physics and Electronics, T.J.P.S. College (PG Courses), Guntur, A.P, India

The constant pursuit in pharmacology and pharmaco-chemistry is to study how efficiently a drug works on a system for a particular disease. Usually physico-chemical and quantum mechanical as well as physical techniques like IR, Raman, have been used to study drug-DNA interactions. Murthy et al. [8–20] were active in correlating the drug activity with physical parameters like electron ionization cross-section and λm. The present work is an extension of the same to anti-inflammatory drugs starting from evaluation of polarizabilities M, diamagnetic susceptibility M and molecular electron ionization cross-section Q and discussing the quantity of dosage and their effects through an algebraic relationship involving Q, dosage, plasma protein binding, bio availability and half-life period. A critical look at the results on Q and dosage reveal that drugs with small Q are highly active and are to be monitored in small quantities and any minute increase in dosage will result in unwanted toxic effects and drugs with high Q are less active and can be monitored in large quantities, without any adverse toxic effects. The algebraic formula enable one to calculate the dosages theoretically from the value of Q and other parameters and the calculated dosage through the formula agreed well with the suggested dosages. For example, in aspirin the calculated equivalent dosage per day is 2.242 g, while the suggested practical dosage is 2.6 g. A similar observation is noted in Sulindac with a theoretical dosage of 0.318 g/day, as against the practical dosage of 0.4 g/day. Thus the present investigations pave the way for a new direction of approach to study the drug activity without using techniques which involve highly expensive instrumentation.

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