MERVAT A. MOHAMED*^#, M.M. MOHAMED**, M.A. KOTB, I.Y. IBRAHIM***

*Biomedical Physics Department, Medical Research Institute, Alexandria University, Egypt
**Medical Equipment Technology Department, Faculty of Allied Medical Science, Pharos University in Alexandria, Egypt
***Forensic Lab, Ministry of Justice, Egypt

The present work focused on investigating the effect of the different doses of Aldicarb on total body, extracellular and intracellular water content and dielectric properties of brain, heart, liver, kidney and leg muscles in Swiss-Albino rats. Control group was fed by standard diet and treated group was divided into two subgroups: Subgroup (2a) orally administered a single dose of aldicarb (0.5 mg/kg bw) 24 hour prior to measurements and Subgroup (2b) orally administered a single lethal dose 50 of aldicarb (lethal dose LD50 = 0.93 mg/kg bw). Percentage of total body water to body weight, percentage of extracellular water and intracellular water to total body water were calculated. Determination of aldicarb concentrations in blood was measured. Permittivity and conductivity of control group and experimental groups at multiple frequencies were measured. Results of this study revealed a significant increase in total body water percentage from 58.68 to 64.10 of group (2a) while a non-significant increase in total body water from 58.68% to 60.38% of group (2b) compared to Control group was obtained; meanwhile, a significant increase in extracellular water percentage from 31.62% to 34.41% of group (2a), but a significant decrease from 31.62% to 28.37%: of group (2b) compared to control group was noticed. A significant decrease in intracellular water percentage from 68.38 to 65.59 of group (2a), but a significant increase from 68.38% to 71.63% of group (2b) compared to control group was also noticed. Concentrations of aldicarb in blood of rats (2a) were of 0.1388±0.0168 mg/L, while blood of rats (2b) presented 5.48±0.322 mg/L. The dielectric properties showed different behavior in permittivity and conductivity of internal organs such as brain, heart, liver, kidney and leg muscles.

Corresponding author’s e-mail: dr_ mervatkh@yahoo.com

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