HEBA KAHIL*^#, H.M. EL_SAYED**, E.M. ELSAYED*, A.M. SALLAM*, MONA TALAAT*, A.A. SATTAR**

*Biophysics Laboratory, Physics Department, Faculty of Science, Ain Shams University, Cairo, Egypt
**Magnetism Laboratory, Physics Department, Faculty of Science, Ain Shams University, Cairo, Egypt

Magnetic fluid hyperthermia (MFH) has been proved to be a promising modality for the treatment of tumors. The specific absorption rate (SAR) is thoroughly investigated in water based colloids; whereas scarce data is available on the SAR values inside biological media. Elevated salt content, presence of proteins and cellular structures are assumed to affect SAR values; a fact that should be considered when determining therapeutic doses. This study presents the preparation of cobalt ferrite magnetic nanoparticles (MNPs) using coprecipitation method with particle size of 13.56 (σ = 0.14) nm and sodium citrate used as coating. The obtained SAR value was 82.6 W/g at a magnetic field intensity of 9.4 kA/m and frequency of 198 kHz in water based fluid and decreased to 23.3 W/g in saline based solution and to a slightly higher value of 29.8 W/g in Ehrlich ascite carcinoma suspension. The effect of MNPs concentration and the therapeutic temperature on the Ehrlich ascite carcinoma cell viability were also studied. This revealed that an optimum concentration of 8 mg/mL and a temperature of 57 ºC led to complete cell death after 30 minutes of exposure at the previously mentioned field and frequency. The results showed that cobalt ferrite can be regarded as a promising candidate for MFH.

Corresponding author’s e-mail: hebakahil@gmail.com

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