DANA PRICOP^#, MARIA ANDRIEȘ

Department of Biophysics and Medical Physics, Faculty of Physics, “Alexandru Ioan Cuza” University, Iași, Romania

The therapeutic effect of the drug molecules in the body strongly depends on the half-life and the internalizing pathways in cells and tissues. In the same time, removal from the body of nanoparticles remains an important objective in the design of drug delivery In recent years, scientific reports have emphasized the main biophysical mechanisms of nanoparticles (NP) interaction with cellular membranes, depending on their size and surface chemistry. This review discusses the optimization of physicochemical properties of nanoparticles focusing on NP size effects in their interaction with living cells. This review highlights the role of NP size and modality of coating to prevent aggregation and agglomeration

Corresponding author’s e-mail: danavered@yahoo.com

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