CRISTINA PÎRVU

Department of Physical-Chemistry, Faculty of Pharmacy, 6, Traian Vuia str., Bucharest, Romania

Abstract. The administration of pharmaceutical forms with normal release and short half-life is done 3–4 times/day. The formulation of some preparations with prolonged release is in this case a useful widely used alternative. One method of creating preparations with prolonged release consiste in microencapsulation of drug. We presented the results of a complex study upon some gelatin microspheres with xantinol nicotinate. The experimental data confirm that the particule size has an influence upon the inflation kinetics as well as active drug release rate.

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