ANA GÂRLEA*, M.I. POPA**, V. POHOAŢĂ*, V. MELNIG*
*Faculty of Physics, “Al.I. Cuza” University, 11A, Carol I Blvd, Iaşi, 700506, Romania
**Faculty of Chemistry, “Gh. Asachi” University, 71A, D. Mangeron, 700050, Iaşi, Romania
Abstract. Vesicles are relatively small and hollow spherical structures which appear as a result of the self-assemblation in aqueous solution of amphiphilic molecules. They are important to be studied for understanding biomembranes and for developing new vehicles for drug delivery. Ibuprofen and ketoprofen are nonsteroidal anti-inflammatory drugs, reducing inflammation, fever and pain in the body. Due to the allergic reactions induced in organism there is necessary to use encapsulated systems. In this paper are presented studies regarding obtaining and stability of these systems. The dimension measurements determined by laser diffraction method reveal that the dimension of vesicles varies from tens of nanometers to hundreds depending on the concentrations and the physical parameters of precursors; by the addition of associating chitosan biopolymer the size and morphology is changed. Spectral UV-VIS concentration measurements show that these vesicles are capable to entrapped drug water solution (50 μg/mL) with a large efficiency.
Key words: lecithin/surfactant vesicles, amphiphilic molecules, ibuprofen/ketoprofen, chitosan.