KUPPAMUTHU SAROJINI^#, H. KRISHNAN

Department of Physics, Valliammai Engineering College, Chennai-603203

This paper deals with molecular docking studies of some synthesized sulfonamide derivatives with the penicilin-binding protein 2X (PBP-2X) protein. The simulation was done using a software package from Schrödinger (LLC, New York). The docking score is analyzed in comparison with the score of cefuroxime used as reference. The most promising derivatives present a score very close to that of cefuroxime. Hydrogen-bonding interactions of the studied sulfonamide compounds with the amino acids of the target protein have been analyzed.

Corresponding author’s e-mail: sarojoe@gmail.com

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