CRISTINA PÎRVU

Department of Physical-Chemistry, Faculty of Pharmacy, 6 Traian Vuia St., Bucharest, Romania

Abstract. For this aim, the microencapsulation of drug (pentoxifylline) was used for creating the preparations with extended release because the drug has short half life (cca 1 h) and frequent administration a day. The microspheres are prepared by emulsification of a gelatin solution in an oil phase. The cross-linking is the glutaraldehyde. In this study, the gelatin microspheres are characterized physicochemical (particle size, particle density, crystalline form of drug, drug content, release kinetics). The release profiles from the studied formulations were evaluated by dissolution models in order to establish release mechanism and kinetics.

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